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KMID : 0903520060490020114
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 2 p.114 ~ p.124
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Inhibitory Effects of Water and 80% Ethanol extracts from Mulberry Leaves (Morus alba L.) on Angiotensin Converting Enzyme and Xanthine Oxidase
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Cho Young-Je
Chun Sung-Sook
Kwon Hyo-Jung
Kim Jeung-Hoan
Lee Kyoung-Hwan
An Bong-Jeun
Choo Jai-Weon
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Abstract
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The objective of this research was to evaluate the ability of water and 80% ethanol extracts from one hundred eight mulberry leaves (Morus alba L.) to influence the inhibitory activity of angiotensin converting enzyme (ACE) and xanthine oxidase (XOase). The total phenol contents were that water extracts of ten species (Kakjayongsan (Morus alba L.), Daejungsun (Morus alba L.) etc.) and 80% ethanol extracts of twenty three species (Waryoung (Morus alba L.), Hasusang (Morus alba L.) etc.) showed more than 15 mg/g. The inhibitory activity on angiotensin converting enzyme (ACE) were that ten species (YamanakkadakKaskke (Morus alba L.), Mijiro (Morus alba L.) etc.) showed 100% inhibition rate both of water extracts and 80% ethanol extracts. The rest, water extracts of thirty four species (Cheongilppong (Morus alba L.) etc.) and 80% ethanol extracts of thirty four species (Wonjukojo (Morus alba L.) etc.) showed inhibitory activity (above 90%) on ACE. Also, to search of xanthine oxidase (XOase) inhibition were that water extracts of five species (Cheongsipjosaeng (Morus alba L.), Suwon 3 (Morus alba L.) etc.) and 80% ethanol extracts of Jeokmok (Morus alba L.) showed inhibitory activity (above 50%) on XOase. This result revealed, strong biological activity in spite of has a little total phenol contents. These water and 80% ethanol extracts from mulberry leaves (Morus alba L.) are expected good candidate for development into anti-hypertentive and anti-gout sources.
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KEYWORD
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biological activity, Mulberry Leaves (Morus alba L.), angiotensin converting enzyme, xanthine oxidase
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